BOTULISM is occurs after ingestion of food contaminated with clostridium Botulinum. Home canned vegetables, smoked meat or vacuum packed fish eating may cause Botulism. The exotoxin liberated from the organism interferes release of acetyl choline at the neuromuscular junction. Four toxin types A, B, E, F cause disease to human beings.
After a brisk gastrointestinal upset patient develops neurological symptoms, including blurring of vision, diplopia, ptosis, dysphasia facial weakness and difficulty in mastication. Limb muscles are paralysed last. Loss of accommodation occurs due to involvement of pupiloconstrictor fibres. CSF is normal. Trivalent antitoxin should be given at once. Guanidine hydrochloride 25-50 mg/kg/day in divided doses will be helpful. Respiratory assistance and other supportive measures should be also valuable. Electrophysiologic findings are same as above.